A model to investigate the oncogenic activity of MLL-fusions in Acute Myeloid Leukaemia
نویسنده
چکیده
...........................................................................................................3 CONTENTS.....................................................................................................................5 LIST OF FIGURES.............................................................................................................. 9 LIST OF TABLES.........................................................................................................13 ABBREVIATIONS ..................................................................................................14 PUBLICATION.............................................................................................................22 ACKNOWLEDGEMENTS..........................................................................................23 CHAPTER I INTRODUCTION .........................................................................................24 1.1. Haematopoiesis .......................................................................................24 1.2. Transcriptional control of haematopoiesis................................................28 1.3. Wnt signalling in haematopoiesis ..............................................................31 1.4. Acute leukaemia in infants .........................................................................34 1.5. MLL and its functional domains................................................................36 1.6. Transcriptional regulation by MLL ...........................................................39 1.7. Normal function of MLL................................................................................42 1.8. MLL oncogenic rearrangements................................................................43 1.9. MLL translocation partner..........................................................................47 1.10. Regulation of gene expression by MLL-fusion ......................................51 1.11. Models of MLL-fusion mediated leukaemia..........................................52 1.12. The cell of origin of MLL-translocations...............................................57 1.13. Leukaemic stem cells...........................................................................59 1.14. Is the MLL-fusion oncogene sufficient to cause leukaemia?.................60
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تاریخ انتشار 2009